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Literature review stem cells
New literature review assesses benefits of stem cells for treatingideally, an ex vivo stroma- and serum-free system supported with known cytokines and growth factors needs to be developed for clinical applications. and gata4 nuclear translocation in tissue-specific mesenchymal stem cells,” stem cells and development, vol. rouabhia, “engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (l-lactide-co-epsilon-caprolactone) scaffold,” journal of biomaterials applications, vol. american association for the advancement of science site on stem cells., “reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells,” the journal of craniofacial surgery, vol. tgf-ß family members have remarkable instructive effects in both es cell26 and neural crest stem cell differentiation., “wnt/β-catenin pathway regulates bone morphogenetic protein (bmp2)-mediated differentiation of dental follicle cells,” journal of periodontal research, vol. kim, “melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis,” journal of pineal research, vol. the findings imply that there is no intrinsic difference between tissue-specific adult stem cells and es cells if a novel environment is provided., “application of induced pluripotent stem (ips) cells in periodontal tissue regeneration,” journal of cellular physiology, vol., “pancreatic differentiation of human dental pulp cd117+ stem cells,” regenerative medicine, vol., “mouse-induced pluripotent stem cells differentiate into odontoblast-like cells with induction of altered adhesive and migratory phenotype of integrin,” plos one, vol., “role of epithelial-stem cell interactions during dental cell differentiation,” the journal of biological chemistry, vol. mao, “clones of ectopic stem cells in the regeneration of muscle defects in vivo,” plos one, vol. laino, and et al, “dental pulp stem cells: a promising tool for bone regeneration,” stem cell reviews, vol.
Adipose-derived stem cells for tissue repair and regeneration: tentheir goal is to systematically study a set of human embryonic stem cells in an effort to establish an international set of standards for characterization. reyes, “vegfr2-dependent angiogenic capacity of pericyte-like dental pulp stem cells,” journal of dental research, vol. they can also differentiate into various progenitor cells, which commit to further maturation along specific lineages. stem cell research has also presented opportunities for clinical science in developing new therapies through the functions of repair, replacement and regeneration., “high-purity hepatic lineage differentiated from dental pulp stem cells in serum-free medium,” journal of endodontics, vol. hyun, “the bioethics of stem cell research and therapy,” the journal of clinical investigation, vol. mostajo-radji, “how induced pluripotent stem cells are redefining personalized medicine,” gene, vol. overcome the limitation of the low frequency of stem cells, researchers have focused on developing protocols for the ex vivo expansion of stem cells.. organizations (note: see a comprehensive list at william hoffman's online map of stem cell research centers)., “early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (grmd) dogs: local or systemic?, “isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice,” plos one, vol. society for stem cell research list of regulations of pluripotent and embryonic stem cell research. sugiyama, “human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration,” cytokine & growth factor reviews, vol. variety of stem cell information, including news and resources for stem cell scientists and non-scientists., “transplantation of stem cells obtained from murine dental pulp improves pancreatic damage, renal function, and painful diabetic neuropathy in diabetic type 1 mouse model,” cell transplantation, vol.
Literature review stem cells +Review of Literature: Stem Cell Treatment of the Heart
Stem Cell Research: R&D Systemssince hematopoietic cells have the potential for providing benefit in a variety of clinical settings, many investigators have explored methods to culture hsc ex vivo to increase the numbers of these cells., “dental pulp-derived cd31-/cd146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats,” tissue engineering a, vol. botero, “dental stem cells and their sources,” dental clinics of north america, vol. they can be self-renewing and are thus able to propagate and generate additional stem cells., “human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation,” cell death and differentiation, vol. of massachusetts's searchable database of published and validated unpublished information on all human embryonic stem cell lines as well as other pluripotent stem cell lines. emara, “advances and challenges in the differentiation of pluripotent stem cells into pancreatic beta cells,” world journal of stem cells, vol., “generation of functional murine cardiac myocytes from induced pluripotent stem cells,” circulation, vol. şahin, “in vitro differentiation of human tooth germ stem cells into endothelial- and epithelial-like cells,” cell biology international, vol. website intended to facilitate communication among scientists, policymakers, journal editors and the public about international scientific collaboration in the area of stem cell research., “differentiation and neuro-protective properties of immortalized human tooth germ stem cells,” neurochemical research, vol., “dental pulp stem cells: state of the art and suggestions for a true translation of research into therapy,” journal of dentistry, vol. alexey bersenev, a researcher at children's hospital of philadelphia, with a focus on both blood stem cells and industry. gronthose, “adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues,” stem cells, vol., “induction of pluripotent stem cells from human third molar mesenchymal stromal cells,” the journal of biological chemistry, vol.
Guide for authors - Stem Cell Research - ISSN 1873-5061heo, “transdifferentiation of human periodontal ligament stem cells into pancreatic cell lineage,” cell biochemistry and function, vol. nagasaka, “promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow,” cell transplantation, vol. state agency that oversees state funds set aside for research and facilities for embryonic and other pluripotent stem cell research., “application of induced pluripotent stem cells in generation of a tissue-engineered tooth-like structure,” tissue engineering—part a, vol.,16 due to the potential problems of ethical regulation and immuno-incompatibility, autologous adult stem cells may represent a promising option for future tissue engineering strategies., “biomaterials coated by dental pulp cells as substrate for neural stem cell differentiation,” journal of biomedical materials research part a, vol. ueda, “osteogenic potential of effective bone engineering using dental pulp stem cells, bone marrow stem cells, and periosteal cells for osseointegration of dental implants,” the international journal of oral & maxillofacial implants, vol. these cells are capable of unlimited, undifferentiated proliferation in vitro and still maintain the capacity for differentiation into a wide variety of somatic and extra- embryonic tissues. huang, “ips cells reprogrammed from human mesenchymal-like stem/progenitor cells of dental tissue origin,” stem cells and development, vol. therefore, adult stem cells may be preferred for future therapeutic applications. funderburgh, “dental pulp stem cells: a new cellular resource for corneal stromal regeneration,” stem cells translational medicine, vol., “stimulation of angiogenesis, neurogenesis and regeneration by side population cells from dental pulp,” biomaterials, vol. the plastic properties of these neural stem cells, identified as nestin positive cells,14 may be manipulated toward a lineage that synthesizes factors of interest and can be used in grafting strategies to replace substances that are lost after injury or in neurodegenerative diseases., “the neuroprotective effect of dental pulp cells in models of alzheimer's and parkinson's disease,” journal of neural transmission, vol. discovery of adult neural stem cells12 and its broad developmental prospective13 has also generated vast interest from researchers.
Regenerative Applications Using Tooth Derived Stem Cells in Other, “shed: stem cells from human exfoliated deciduous teeth,” proceedings of the national academy of sciences of the united states of america, vol. bhonde, “dental pulp stem cells immobilized in alginate microspheres for applications in bone tissue engineering,” international endodontic journal, vol. expression data for hematopoetic stem cells and their microenvironments from labs at mt. shi, “critical reviews in oral biology & medicine: mesenchymal stem cells derived from dental tissues vs. the question of whether adult stem cells can fulfill the same promise as es cells, however, remains uncertain. these studies suggest the feasibility in identifying conditions required for functional mature cell induction of es cells., “physiological features of periodontal regeneration and approaches for periodontal tissue engineering utilizing periodontal ligament cells,” journal of bioscience and bioengineering, vol., “osteoblastic/cementoblastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine,” tissue engineering part b: reviews, vol., a true stem cell population needs to be identified in vivo before any in vitro manipulation can occur. and commentaries by scientists on how to translate stem cell research to the clinic. one of the important extracellular signals that controls stem cell fate is the secretion of growth and differentiation factors., “feeder-free derivation of induced pluripotent stem cells from human immature dental pulp stem cells,” cell transplantation, vol. these functional properties of stem cells have attracted significant interest from both basic and clinical science researchers., “comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells,” plos one, vol. bone marrow-derived stem cells (bmsc) can differentiate into various cell types: adipocytes, chondrocytes, osteocytes, hepatocytes, cardiomyocytes and neurons.
New literature review assesses benefits of stem cells for treating
Publication: LITERATURE REVIEW ON STEM CELL TREATMENT, “transplantation of islet-like cell clusters derived from human dental pulp stem cells restores normoglycemia in diabetic mice,” cytotherapy, vol. in the past several years, this field has been flooded with reports on differentiating stem cells into various mature cells both in vitro and in vivo (figure 1)..A report of in vitro differentiation of es cells demonstrated the use of fgf-2, ascorbic acid, sonic hedgehog (shh) and fgf-8 to obtain dopaminergic (da) and serotonergic neurons in high yield from mouse es cells. therefore, discoveries of new growth factors or new functions of existing factors could promote the progress of studies in stem cell expansion. chan, “putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice,” stem cells, vol. multilineage cells have also been identified from epithelial and adipose tissues., “glial origin of mesenchymal stem cells in a tooth model system,” nature, vol. major focus in stem cell research is the manipulation of cells to differentiate into a targeted population., “control of proliferation and osteogenic differentiation of human dental-pulp-derived stem cells by distinct surface structures,” acta biomaterialia, vol. yamanaka, “induced pluripotent stem cells: past, present, and future,” cell stem cell, vol., “human dental pulp cells: a new source of cell therapy in a mouse model of compressive spinal cord injury,” journal of neurotrauma, vol. lalykina, “the development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells,” cell and tissue kinetics, vol. registry of pluripotent cell lines eligible for federal funding, including embryonic stem cells that have met criteria set out in the code of practice for the use of human stem cell lines., “transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts,” plos one, vol., “in vitro differentiation into insulin-producing β-cells of stem cells isolated from human amniotic fluid and dental pulp,” digestive and liver disease, vol.
SEMS Year 3 project Literature Review Text 1 1.1 Stem cells and, “human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms,” the journal of clinical investigation, vol. stem cell populations have been discovered from various adult tissues. miettinen, “characterisation of human dental stem cells and buccal mucosa fibroblasts,” biochemical and biophysical research communications, vol. liu, “enhancement of periodontal tissue regeneration by transplantation of osteoprotegerin-engineered periodontal ligament stem cells,” stem cell research & therapy, vol., “the osteoblastic differentiation of dental pulp stem cells and bone formation on different titanium surface textures,” biomaterials, vol. gronthos, “immunomodulatory properties of human periodontal ligament stem cells,” journal of cellular physiology, vol. interleukin-3 (il-3), stem cell factor (scf), and flt-3 ligand (fl) are potential candidates for expansion strategies due to their early acting and lineage-unspecific hematopoietic stimulation., “stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells,” stem cells and development, vol. stem cell research center human embryonic stem cell core facility., “bone repair by periodontal ligament stem cell-seeded nanohydroxyapatite-chitosan scaffold,” international journal of nanomedicine, vol. recent evidence casts some uncertainty on the benefits of using a single cell marker in cell isolation for stem cell research until more is known about the novel marker-negative stem cell population. embryonic stem cells (es), which are derived from the inner cell mass of preimplantation embryos1 have been recognized as the most pluripotent stem cell population., “periodontal ligament stem cells possess the characteristics of pericytes,” journal of periodontology, vol., “induced pluripotent stem cells generated from patients with als can be differentiated into motor neurons,” science, vol. east england stem cell network, durham university and newcastle university.
Links : Nature Reports Stem Cellsabout, “quantification of angiogenic growth factors released by human dental cells after injury,” archives of oral biology, vol., “isolation and in vitro characterisation of dental pulp stem cells from natal teeth,” histochemistry and cell biology, vol. "network of networks" to unify international efforts on stem cell science. freely accessible database of more than 175 human embryonic stem cell lines containing user-provided information on the cell lines or information on their research., “human amniotic fluid-derived and dental pulp-derived stem cells seeded into collagen scaffold repair critical-size bone defects promoting vascularization,” stem cell research & therapy, vol. gearhart, “the end of the beginning for pluripotent stem cells,” nature, vol., “dental pulp cells for induced pluripotent stem cell banking,” journal of dental research, vol. although the es cell has the greatest developmental potential, the ethical dispute revolving around the use of embryonic cells or tissues precludes these cells from experimentation and application., “investigation of multipotent postnatal stem cells from human periodontal ligament,” the lancet, vol., “micro-ct and pet analysis of bone regeneration induced by biodegradable scaffolds as carriers for dental pulp stem cells in a rat model of calvarial ‘critical size’ defect: preliminary data,” journal of biomedical materials research part b: applied biomaterials, vol., “human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction,” stem cells, vol., “human cd34+ stem cells produce bone nodules in vivo,” cell proliferation, vol. they can also differentiate into various progenitor cells, which may then commit to further maturation along specific lineages. university of wisconsin-based repository to grow, characterize and distribute some of the pluripotent stem cell lines listed on the national institutes of health stem cell registry. shi, “postnatal human dental pulp stem cells (dpscs) in vitro and in vivo,” proceedings of the national academy of sciences of the united states of america, vol.
database of 260 embryonic stem cells worldwide, maintained by labs at the scripps research institute. latest news, comment and analysis on stem cell research and its implications. neural precursor cells have been successfully isolated from the developing human cortex and expanded in the presence of both egf and fibroblast growth factor-2 (fgf-2). jain, “current overview on dental stem cells applications in regenerative dentistry,” journal of natural science, biology and medicine, vol. most of the work in isolating stem cells, however, was performed in a relative in vitro, "simulated" format., “alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot study,” journal of periodontology, vol., “integration of neuronally predifferentiated human dental pulp stem cells into rat brain in vivo,” neurochemistry international, vol., “angiogenic properties of human dental pulp stem cells,” plos one, vol. scheven, “a comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue, bone marrow and dental pulp,” journal of bone and mineral metabolism, vol. yamanaka, “induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” cell, vol. in addition to secreted factors, integral membrane proteins as well as integrins and the extracelluar matrix also contribute to the microenvironment of stem cells in determining their fate. koblar, “neurogenic potential of dental pulp stem cells isolated from murine incisors,” stem cell research & therapy, vol., “a feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone-marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology,” tissue engineering part a, vol. the "stem cell" concept was introduced decades ago, to date, stem cells can only be defined functionally, not morphologically or phenotypically. institutes of health's listing of current scientific articles about stem cell research.
, “human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes,” european cells and materials, vol. nosrat, “dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury,” developmental biology, vol. gava, “mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration,” brazilian dental journal, vol. jin, “ameloblasts serum-free conditioned medium: bone morphogenic protein 4-induced odontogenic differentiation of mouse induced pluripotent stem cells,” journal of tissue engineering and regenerative medicine, 2013. kim, “comparison of the effects of human dental pulp stem cells and human bone marrow-derived mesenchymal stem cells on ischemic human astrocytes in vitro,” journal of neuroscience research, vol. european union project concerned with the ethics of human stem cell research and therapy. channels plays a crucial role in the neural differentiation of dental pulp stem cells,” plos one, vol., “tooth-derived stem cells: update and perspectives,” world journal of stem cells, vol., “engineering bone formation from human dental pulp- and periodontal ligament-derived cells,” annals of biomedical engineering, vol. ueda, “multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury,” neuroscience research, vol. jansen, “hard tissue formation of stro-1-selected rat dental pulp stem cells in vivo,” tissue engineering a, vol. the challenge of maintaining the stem cell's undifferentiated, multilineage potency during its long-term expansion, however, is great. the characteristics and potential uses of ucb stem cells are currently under extensive examination., “ex vivo bone morphogenetic protein 2 gene delivery using periodontal ligament stem cells for enhanced re-osseointegration in the regenerative treatment of peri-implantitis,” journal of biomedical materials research a, vol., “endothelial progenitor cells from human dental pulp-derived ips cells as a therapeutic target for ischemic vascular diseases,” biomaterials, vol.
Adipose-derived stem cells for tissue repair and regeneration: ten
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stem cell institute's online review of stem cell biology containing original, peer-reviewed, open-access content on topics related to stem cell biology., “treatment of salivary gland hypofunction by transplantation with dental pulp cells,” archives of oral biology, vol. agency to support and commercialize stem cell research to create treatments for human disease. white, “dental pulp stem cells: function, isolation and applications in regenerative medicine,” journal of tissue engineering and regenerative medicine, 2014., “effects of adenoviral-mediated coexpression of bone morphogenetic protein-7 and insulin-like growth factor-1 on human periodontal ligament cells,” journal of periodontal research, vol. the generation of insulin-expressing cells from mouse es cells, both in vitro and in vivo, has also been reported. addition to providing core facilities to members of the harvard stem cell institute, the institute's induced pluripotent stem (ips) cell core facility promotes the distribution of ips lines, including those derived from individuals with diseases of the nervous system, blood and kidney as well as from individuals with diabetes. liang, “periodontal ligament stem cells: current status, concerns, and future prospects,” stem cells international, vol. jansen, “mineralized tissue formation by bmp2-transfected pulp stem cells,” journal of dental research, vol. to fund collaborative projects and promote good practices in stem cell research. wang, “periodontal ligament versus bone marrow mesenchymal stem cells in combination with bio-oss scaffolds for ectopic and in situ bone formation: a comparative study in the rat,” journal of biomaterials applications, vol. longaker, “stem cells: review and update,” archives of surgery, vol. akiyama, “stem cells in dentistry—part i: stem cell sources,” journal of prosthodontic research, vol. one type of adult stem cell population known for its important role in hematopoietic reconstitution is the hematopoietic stem cell (hsc). in vitro technologies based on the recognition of stem cell surface markers, such as cd34,17 ac133,18 stro-1,19 and neurotrophin receptor p7520 have been used to purify stem cells, including panning, fluorescence-activated cell sorting, immunomagnetic selection and immunoadsorption column separation.
Stem Cell Research: R&D Systems
, “a new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (lab),” journal of bone and mineral research, vol. all of these studies attempting to expand stem cells and progenitor cells in vitro have become possible over the past decade due to the availability of recombinant growth factors and cell selection technologies., “hydrogen sulphide increases hepatic differentiation of human tooth pulp stem cells compared with human bone marrow stem cells,” international endodontic journal, vol., “human dental pulp stem cells protect mouse dopaminergic neurons against mpp+ or rotenone,” brain research, vol., “periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine,” stem cells, vol., “inherent differential propensity of dental pulp stem cells derived from human deciduous and permanent teeth,” journal of endodontics, vol. stem cells are capable of propagating and generating additional stem cells., “5-aza-2′-deoxycytidine treatment induces skeletal myogenic differentiation of mouse dental pulp stem cells,” archives of oral biology, vol. retired journalist david jensen, about policy relating to the california stem cell report., “donor-matched comparison of dental pulp stem cells and bone marrow-derived mesenchymal stem cells in a rat model,” journal of tissue engineering and regenerative medicine, vol., “potential role of dental stem cells in the cellular therapy of cerebral ischemia,” current pharmaceutical design, vol. stem cells to their own internal program project grant aimed at treating spinal cord injury and also provides resources to new jersey scientists conducting human embryonic stem cell research, including non-federally restricted laboratory space to aid in pilot projects.-review: cytokine regulation during embryonic hematopoiesismini-review: dendritic cell maturationmini-review: stem cell markersresearch area: stem cells. umbrella organisation and communication platform for stem cell research in germany. cheung, “plasticity of stem cells derived from adult periodontal ligament,” regenerative medicine, vol.
, “corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells,” investigative ophthalmology and visual science, vol., “novel management of acute or secondary biliary liver conditions using hepatically differentiated human dental pulp cells,” tissue engineering a, vol.-10 the developing and adult mammalian central nervous system contains a population of undifferentiated, multipotent cell precursors, neural stem cells (nsc). daniels, “culture and characterization of oral mucosal epithelial cells on a fibrin gel for ocular surface reconstruction,” current eye research, 2014., “reconstruction of alveolar bone defects using bone morphogenetic protein 2 mediated rabbit dental pulp stem cells seeded on nano-hydroxyapatite/collagen/poly(l-lactide),” tissue engineering part a, vol., “a novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp,” stem cells, vol. lambrichts, “dental stem cells and their promising role in neural regeneration: an update,” clinical oral investigations, vol. the definition of the stem cell is best given functionally, identification and isolation of this unique cell population have become challenging tasks. scheven, “intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury,” investigative ophthalmology & visual science, vol., “differentiation of mouse embryonic stem cells into dental epithelial-like cells induced by ameloblasts serum-free conditioned medium,” biochemical and biophysical research communications, vol. the fundamental scheme of stem cells provides a model for basic science researchers to study developmental biology from a very early stage. duruksu, “human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells,” histochemistry and cell biology, vol. a similar population of dormant cd34-negative hematopoietic stem cells has also been discovered in humans. lambrichts, “dental stem cells in pulp regeneration: near future or long road ahead? sato, “in vitro analysis of mesenchymal stem cells derived from human teeth and bone marrow,” odontology, vol.
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